ITM2B Polyclonal Antibody

• Background:

  Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.

• Description:

  This is a ITM2B Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  ITM2B, ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD, RDGCA, imBRI2

• Gene ID:

  9445

• Swiss Prot:

  Q9Y287

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant fusion protein of human ITM2B

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1mg/mL

• Dilution:

  WB 1:500-1:2000

• Buffer:

  PBS with 0.01% thiomersal,50% glycerol, pH7.3.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  71kDa/77kDa/83kDa/111kDa/117kDa/120kDa/122kDa

• Observed Molecular Weight:

  123kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG