TRPM8 Polyclonal Antibody

CAT: 0866-RD87478A-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0866-RD87478A-01Size:60 μL
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Background
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration. Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.
Description
This is a TRPM8 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
TRPM8, LTRPC6, TRPP8
Gene ID
79054
Swiss Prot
Q7Z2W7
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human TRPM8
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.01% thiomersal,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
23kDa/109kDa/134kDa/149kDa/163kDa
Observed Molecular Weight
164kDa
Host or Source
Rabbit
Isotype
IgG

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