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SHARPIN Polyclonal Antibody

CAT: 0866-RD87361A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD87361A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.
Description
This is a SHARPIN Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
SHARPIN, SIPL1, sharpin
Gene ID
81858
Swiss Prot
Q9H0F6
Reactivity
Human, Rat
Immunogen
Recombinant fusion protein of human SHARPIN
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.01% thiomersal,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
34kDa/56kDa
Observed Molecular Weight
56kDa
Host or Source
Rabbit
Isotype
IgG

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