LAPTM4B Polyclonal Antibody

• Background:

  Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter to the lysosome, promoting entry of leucine and other essential amino acid (EAA into the lysosome, stimulating activation of proton-transporting vacuolar (V-ATPase protein pump (V-ATPase and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways.

• Description:

  This is a LAPTM4B Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  LAPTM4B, LAPTM4beta, LC27

• Gene ID:

  55353

• Swiss Prot:

  Q86VI4

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein of human LAPTM4B

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1mg/mL

• Dilution:

  WB 1:500-1:2000

• Buffer:

  PBS with 0.01% thiomersal,50% glycerol, pH7.3.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  19kDa/25kDa/44kDa

• Observed Molecular Weight:

  45kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG