NCF4 Polyclonal Antibody

CAT: 0866-RD86809A-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0866-RD86809A-01Size:60 μL
Selected
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI (3) kinase, which suggests its role in PI (3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Description
This is a NCF4 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
NCF4, CGD3, NCF, P40PHOX, SH3PXD4
Gene ID
4689
Swiss Prot
Q15080
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human NCF4
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.01% thiomersal,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
46kDa
Observed Molecular Weight
48KDa
Host or Source
Rabbit
Isotype
IgG

Popular Products