Cyclin D2 Polyclonal Antibody

• Background:

  The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3) .

• Description:

  This is a Cyclin D2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  CCND2, KIAK0002, MPPH3, cyclin D2, Cyclin D2

• Gene ID:

  894

• Swiss Prot:

  P30279

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein of human Cyclin D2

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:2000

• Buffer:

  PBS with 0.02% sodium azide,50% glycerol, pH7.3.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  25kDa/34kDa/35kDa

• Observed Molecular Weight:

  40KDa

• Host or Source:

  Rabbit

• Isotype:

  IgG