MET Polyclonal Antibody

• Background:

  This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.

• Description:

  This is a MET Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  MET, AUTS9, DFNB97, HGFR, RCCP2, c-Met

• Gene ID:

  4233

• Swiss Prot:

  P08581

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein of human MET

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB, IHC

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1mg/mL

• Dilution:

  WB 1:500-1:2000, IHC 1:50-1:200

• Buffer:

  PBS with 0.01% thiomersal,50% glycerol, pH7.3.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  66kDa

• Observed Molecular Weight:

  66kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG