Products for Research Use Only
RegisterLogin

SARM1 Polyclonal Antibody

CAT: 0866-RD89329A-01Size: 60 μLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0866-RD89329A-01Size:60 μL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
NAD (+ hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD (+ metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD (+ depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD (+ into ADP-D-ribose (ADPR, cyclic ADPR (cADPR and nicotinamide; NAD (+ cleavage promoting cytoskeletal degradation and axon destruction. Also able to hydrolyze NADP (+, but not other NAD (+-related molecules. Can activate neuronal cell death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity. Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.
Description
This is a SARM1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
SARM, HsTIR, SAMD2, hSARM1, MyD88-5
Gene ID
23098
Swiss Prot
Q6SZW1
Reactivity
Human
Immunogen
A synthetic peptide of human SARM1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IP
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000, IP 1:50-1:200
Buffer
PBS with 0.05% proclin300,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
50kDa
Observed Molecular Weight
58KDa
Host or Source
Rabbit
Isotype
IgG

Related Products

CatalogName
RD81942A-01Polyclonal AntibodyPC1 Polyclonal Antibody
RD83593A-01Polyclonal AntibodyPC4 Polyclonal Antibody
RD77496A-01MAG Polyclonal Antibody
RD77501A-01MCM6 Polyclonal Antibody
RD219935A-01ATP5I Polyclonal Antibody
RD75037A-01TONSL Polyclonal Antibody
RD218583A-01CALHM1 Polyclonal Antibody
RD217759A-01CAD Polyclonal Antibody
RD76666A-01PRKCA Polyclonal Antibody
RD218556A-01C15orf40 Polyclonal Antibody

Alternative Products

CatalogName
MBS8531848-01SARM1 Polyclonal Antibody
NBP1-77200-0.025mgRabbit Polyclonal SARM1 Antibody
GTR17730547-01SARM1 Rabbit Polyclonal Antibody
TMAB-12507-01Anti-SARM1 Polyclonal Antibody
GTR17813246SARM1 Rabbit Polyclonal Antibody (APC)
OALA01808-50UGSARM1 Antibody

Popular Products