MAML2 Polyclonal Antibody

• Background :

  The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL) . Copy number variation in the polyglutamine tract has been observed.

• Description :

  This is a MAML2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms :

  MAML2, MAM-3, MAM2, MAM3, MLL-MAML2

• Gene ID :

  84441

• Swiss Prot :

  Q8IZL2

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  A synthetic peptide of human MAML2

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Polyclonal Antibody

• Applications :

  WB, IF

• Purification Method :

  Affinity purification

• Assay Type :

  Antibody

• Concentration :

  1mg/mL

• Dilution :

  WB 1:500-1:2000, IF 1:50-1:200

• Buffer :

  PBS with 0.01% thiomersal,50% glycerol, pH7.3.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Observed Molecular Weight :

  12kDa

• Host or Source :

  Rabbit

• Isotype :

  IgG