S100A8 Polyclonal Antibody

• Background :

  S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9 which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities.

• Description :

  This is a S100A8 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms :

  P, Ca, MR, p8, B8A, CFA, B8Ag, CFAg, CP-1, Caga, MRP8, 60B8A, CP-10, 60B8Ag, AI323541

• Gene ID :

  20201

• Swiss Prot :

  P27005

• Reactivity :

  Mouse, Rat

• Immunogen :

  Recombinant fusion protein of mouse S100A8

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Polyclonal Antibody

• Applications :

  WB, IHC

• Purification Method :

  Affinity purification

• Assay Type :

  Antibody

• Concentration :

  1mg/mL

• Dilution :

  WB 1:500-1:2000, IHC 1:50-1:200

• Buffer :

  PBS with 0.05% proclin300,50% glycerol, pH7.3.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  76kDa

• Observed Molecular Weight :

  130KDa

• Host or Source :

  Rabbit

• Isotype :

  IgG