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S100A8 Polyclonal Antibody

CAT: 0866-RD90269A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD90269A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9 which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities.
Description
This is a S100A8 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
P, Ca, MR, p8, B8A, CFA, B8Ag, CFAg, CP-1, Caga, MRP8, 60B8A, CP-10, 60B8Ag, AI323541
Gene ID
20201
Swiss Prot
P27005
Reactivity
Mouse, Rat
Immunogen
Recombinant fusion protein of mouse S100A8
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Buffer
PBS with 0.05% proclin300,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
76kDa
Observed Molecular Weight
130KDa
Host or Source
Rabbit
Isotype
IgG

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