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HB-EGF Polyclonal Antibody

CAT: 0866-RD88705A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD88705A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Heparin-binding EGF-like growth factor (HB-EGF) is a 12-16 kDa member of the epidermal growth factor (EGF) family. It possesses an EGF-like domain, and a heparin-binding motif. Mature HB-EGF is a soluble peptide thatarises from proteolytic processing of the transmembrane form. Human HB -EGF shows 76% and 73% aasequence identity with rat and mouse HB-EGF, respectively. It is required for normal cardiac valve formationand normal heart function, promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation; it is mitogenic for fibroblasts, but not endothelial cells. HB-EGF classified as agroup 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors. Activityassociated with ErbB4 binding appears to be limited to non -mitogenic actions, while EGFR binding inducesboth mitogenic and non-mitogenic activity.
Description
This is a HB-EGF Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
HBEGF, DTR, DTS, DTSF, HEGFL
Gene ID
1839
Swiss Prot
Q99075
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human HB-EGF
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IF
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000, IF 1:50-1:200
Buffer
PBS with 0.05% proclin300,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
67kDa/81kDa
Observed Molecular Weight
130kDa
Host or Source
Rabbit
Isotype
IgG

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