GDNF Polyclonal Antibody

• Background :

  This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing.

• Description :

  This is a GDNF Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms :

  GDNF, ATF, ATF1, ATF2, HFB1-GDNF, HSCR3

• Gene ID :

  2668

• Swiss Prot :

  P39905

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein of human GDNF

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Polyclonal Antibody

• Applications :

  WB, IF

• Purification Method :

  Affinity purification

• Assay Type :

  Antibody

• Concentration :

  1mg/mL

• Dilution :

  WB 1:500-1:2000, IF 1:50-1:200

• Buffer :

  PBS with 0.01% thiomersal,50% glycerol, pH7.3.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  33kDa/45kDa/46kDa

• Observed Molecular Weight :

  47kDa

• Host or Source :

  Rabbit

• Isotype :

  IgG