Thyroglobulin Polyclonal Antibody

• Background:

  Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.

• Description:

  This is a Thyroglobulin Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  TG, AITD3, TGN

• Gene ID:

  7038

• Swiss Prot:

  P01266

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant fusion protein of human Thyroglobulin

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB, IHC

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1mg/mL

• Dilution:

  WB 1:500-1:2000, IHC 1:50-1:200

• Buffer:

  PBS with 0.01% thiomersal,50% glycerol, pH7.3.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  85kDa/88kDa

• Observed Molecular Weight:

  110kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG