Bcl10 Polyclonal Antibody

• Background:

  This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.

• Description:

  This is a Bcl10 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  BCL10, CARMEN, CIPER, CLAP, IMD37, c-E10, mE10

• Gene ID:

  8915

• Swiss Prot:

  O95999

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant fusion protein of human Bcl10

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1mg/mL

• Dilution:

  WB 1:500-1:1000

• Buffer:

  PBS with 0.05% proclin300,50% glycerol, pH7.3.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  40kDa/43kDa

• Observed Molecular Weight:

  46kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG