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STAT1 Polyclonal Antibody

CAT: 0866-RD90709A-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0866-RD90709A-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Signal transducer and activator of transcription that mediates signaling by interferons (IFNs) . Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
Description
This is a STAT1 Polyclonal antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
Signal transducer and activator of transcription 1 91kD, CANDF7, DKFZp686B04100, IMD31A, IMD31B, IMD31C, ISGF 3, ISGF-3, OTTHUMP00000163552, OTTHUMP00000165046, OTTHUMP00000165047, OTTHUMP00000205845, Signal transducer and activator of transcription 1 91kDa, Signal tr
Swiss Prot
P42224
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant Human STAT1 Protein expressed by E.coli
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal antibody
Applications
WB, IHC
Purification Method
Antigen affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:1000, IHC 1:50-1:100
Buffer
PBS with 0.02% sodium azide,50% glycerol pH 7.4
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
15kDa
Observed Molecular Weight
15kDa
Host or Source
Rabbit
Isotype
IgG

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