E-Cadherin Polyclonal Antibody

CAT: 0866-RD90073A-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0866-RD90073A-01Size:60 μL
Selected
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
Description
This is a E-Cadherin Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
Arc-1, CD324, CDHE, ECAD, LCAM, UVO, CDH1, E-Cadherin
Gene ID
999
Swiss Prot
P12830
Reactivity
Human, Rat
Immunogen
A synthetic peptide of human E-Cadherin
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC, IF
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000, IHC 1:50-1:100, IF 1:50-1:200
Buffer
PBS with 0.01% thiomersal,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
51kDa/52kDa
Observed Molecular Weight
53kDa
Host or Source
Rabbit
Isotype
IgG

Popular Products