E-Cadherin Polyclonal Antibody

• Background:

  This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.

• Description:

  This is a E-Cadherin Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  Arc-1, CD324, CDHE, ECAD, LCAM, UVO, CDH1, E-Cadherin

• Gene ID:

  999

• Swiss Prot:

  P12830

• Reactivity:

  Human, Rat

• Immunogen:

  A synthetic peptide of human E-Cadherin

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB, IHC, IF

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1mg/mL

• Dilution:

  WB 1:500-1:2000, IHC 1:50-1:100, IF 1:50-1:200

• Buffer:

  PBS with 0.01% thiomersal,50% glycerol, pH7.3.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  51kDa/52kDa

• Observed Molecular Weight:

  53kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG