CDK12 Polyclonal Antibody

CAT: 0866-RD88038A-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0866-RD88038A-01Size:60 μL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD of the large subunit of RNA polymerase II (POLR2A, thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
Description
This is a CDK12 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
CDK12, CRK7, CRKR, CRKRS
Gene ID
51755
Swiss Prot
Q9NYV4
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human CDK12
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Buffer
PBS with 0.05% proclin300,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
41kDa
Observed Molecular Weight
53kDa
Host or Source
Rabbit
Isotype
IgG

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