CDK12 Polyclonal Antibody

• Background:

  Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD of the large subunit of RNA polymerase II (POLR2A, thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.

• Description:

  This is a CDK12 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  CDK12, CRK7, CRKR, CRKRS

• Gene ID:

  51755

• Swiss Prot:

  Q9NYV4

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein of human CDK12

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB, IHC

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1mg/mL

• Dilution:

  WB 1:500-1:2000, IHC 1:50-1:200

• Buffer:

  PBS with 0.05% proclin300,50% glycerol, pH7.3.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  41kDa

• Observed Molecular Weight:

  53kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG