MDC1 Polyclonal Antibody

• Background :

  The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.

• Description :

  This is a MDC1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms :

  MDC1, NFBD1

• Gene ID :

  9656

• Swiss Prot :

  Q14676

• Reactivity :

  Human, Mouse

• Immunogen :

  A synthetic peptide of human MDC1

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Polyclonal Antibody

• Applications :

  WB, IHC, IF

• Purification Method :

  Affinity purification

• Assay Type :

  Antibody

• Concentration :

  1mg/mL

• Dilution :

  WB 1:500-1:2000, IHC 1:50-1:200, IF 1:50-1:200

• Buffer :

  PBS with 0.01% thiomersal,50% glycerol, pH7.3.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  25kDa

• Observed Molecular Weight :

  29kDa

• Host or Source :

  Rabbit

• Isotype :

  IgG