ITCH Polyclonal Antibody

• Background:

  This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

• Description:

  This is a ITCH Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  ITCH, ADMFD, AIF4, AIP4, NAPP1

• Gene ID:

  83737

• Swiss Prot:

  Q96J02

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein of human ITCH

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB, IHC

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1mg/mL

• Dilution:

  WB 1:500-1:2000, IHC 1:50-1:100

• Buffer:

  PBS with 0.01% thiomersal,50% glycerol, pH7.3.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  39kDa/53kDa/56kDa/61kDa

• Observed Molecular Weight:

  57kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG