Cinacalcet

• Description:

  Cinacalcet (AMG 073) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease research.

• Product Name Alternative:

  AMG 073

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H320

• Target:

  CaSR; Endogenous Metabolite

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Cinacalcet.html

• Purity:

  99.93

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  FC(F)(C1=CC(CCCN[C@@H](C2=C3C=CC=CC3=CC=C2)C)=CC=C1)F

• Molecular Formula:

  C22H22F3N

• Molecular Weight:

  357.41

• Precautions:

  H315, H319, H320

• References & Citations:

  [1]Colloton M, et al. Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism. Kidney Int. 2005 Feb;67 (2) :467-76.|[2]D.A. Bushinsky, et al. Effect of cinacalcet on urine calcium excretion and supersaturation in genetic hypercalciuric stone-forming rats. Kidney Int. 2006 May;69 (9) :1586-92.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Citation 01:

  Acta Physiol. 2023 Apr;237 (4) :e13926.|bioRxiv. 2025 Sep 21.|Calcif Tissue Int. 2023 Apr;112 (4) :452-462.|Cell Biol Toxicol. 2023 Oct;39 (5) :1-17.|Gen Comp Endocrinol. 2018 Oct 1:267:1-8.|J Agric Food Chem. 2021 Nov 17;69 (45) :13460-13473.|J Biol Chem. 2016 Oct 28;291 (44) :23126-23135.|J Clin Endocrinol Metab. 2024 Oct 16:dgae735.|J Food Sci. 2018 Sep;83 (9) :2394-2401.|J Med Chem. 2015 Apr 9;58 (7) :2958-66. |Oxid Med Cell Longev. 2017:2017:3869561.|Oxid Med Cell Longev. 2021 Jan 12;2021:3010548.|Adv Mater. 2024 Jun;36 (24) :e2311760.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|iScience. 2023 Mar 11;26 (4) :106378.|J Funct Foods. 2025 Apr.|Patent. US20230147129A1.

• CAS Number:

  [226256-56-0]