Cinacalcet

• UNSPSC Description:

  Cinacalcet (AMG 073) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease research.

• Target Antigen:

  CaSR; Endogenous Metabolite

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Cinacalcet.html

• Purity:

  99.97

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  FC(F)(C1=CC(CCCN[C@@H](C2=C3C=CC=CC3=CC=C2)C)=CC=C1)F

• Molecular Weight:

  357.41

• References & Citations:

  [1]Colloton M, et al. Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism. Kidney Int. 2005 Feb;67(2):467-76.|[2]D.A. Bushinsky, et al. Effect of cinacalcet on urine calcium excretion and supersaturation in genetic hypercalciuric stone-forming rats. Kidney Int. 2006 May;69(9):1586-92.Acta Physiol. 2023 Jan 6;e13926.|Calcif Tissue Int. 2023 Feb 8.|Cell Biol Toxicol. 2022 May 30.|Gen Comp Endocrinol. 2018 Oct 1;267:1-8.|J Agric Food Chem. 2021 Nov 8.|J Biol Chem. 2016 Oct 28;291(44):23126-23135.|J Food Sci. 2018 Sep;83(9):2394-2401.|J Med Chem. 2015 Apr 9;58(7):2958-66. |Oxid Med Cell Longev. 2017;2017:3869561.|Oxid Med Cell Longev. 2021 Jan 12;2021:3010548.|Adv Mater. 2024 Jun;36(24):e2311760.|Cell Rep Methods. 2023 Oct 23;3(10):100599.|iScience. 2023 Mar.|Patent. US20230147129A1.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  226256-56-0