Phospho-FAK (Tyr397) Polyclonal Antibody

• Background:

  Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

• Description:

  This is a Phospho-FAK (Tyr397) Phospho-Specific Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  FADK 1, FADK, FAK related non kinase polypeptide, FAK1, FAK1, Focal adhesion kinase 1, Focal adhesion Kinase, Focal adhesion kinase isoform FAK Del33, Focal adhesion kinase related nonkinase, FRNK, p125FAK, pp125FAK, PPP1R71, Protein phosphatase 1 regulatory subunit 7

• Swiss Prot:

  Q05397

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthesized peptide derived from human FAK around the phosphorylation site of Tyr397

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Phospho-Specific Antibody

• Applications:

  WB, IHC-p, ELISA

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000

• Buffer:

  PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  119 kDa

• Observed Molecular Weight:

  119 kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG