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Anecortave acetate

CAT: 0804-HY-116868-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-116868-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Anecortave acetate is a potent ocular angiostatic agent. Anecortave acetate inhibits neovascularization which is induced by many different angiogenic factors, and increases plasminogen activator inhibitor-1 (PAI-1) mRNA expression. Anecortave acetate can be used to research ocular neovascular diseases[1][2].
CAS Number
7753-60-8
Product Name Alternative
Anecortave
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
PAI-1
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/anecortave-acetate.html
Purity
99.81
Solubility
Methanol : 1 mg/mL (ultrasonic)
Smiles
C[C@@]12[C@](O)(CC[C@]1([C@@]3(CCC4=CC(CC[C@@]4(C3=CC2)C)=O)[H])[H])C(COC(C)=O)=O
Molecular Formula
C23H30O5
Molecular Weight
386.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Clark AF. Mechanism of action of the angiostatic cortisene anecortave acetate. Surv Ophthalmol. 2007 Jan;52 Suppl 1:S26-34.|[2]Penn JS, et al. The effect of an angiostatic steroid on neovascularization in a rat model of retinopathy of prematurity. Invest Ophthalmol Vis Sci. 2001 Jan;42 (1) :283-90.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

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