PAX5 Polyclonal Antibody

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t (9;14) (p13; q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms.

This is a PAX5 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

PAX5, ALL3, BSAP

5079

Q02548

Human

Recombinant fusion protein of human PAX5 (NP_057953.1) .

Unconjugated

Polyclonal Antibody

WB

Affinity purification

Antibody

1 mg/mL

WB 1:1000-1:3000

PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Store at -20°C. Avoid freeze / thaw cycles.

31 kDa/32 kDa/34 kDa/35 kDa/37 kDa/38 kDa/42 kDa

42 kDa

Rabbit