LEPR Polyclonal Antibody

• Background:

  The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021) .

• Description:

  This is a LEPR Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  CD295, LEP-R, LEPRD, OB-R, OBR, LEPR

• Gene ID:

  3953

• Swiss Prot:

  P48357

• Reactivity:

  Human

• Immunogen:

  A synthetic peptide of human LEPR

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:1000

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  96 kDa/102 kDa/103 kDa/109 kDa/132 kDa

• Observed Molecular Weight:

  113 kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG