DNMT3B Polyclonal Antibody

• Background:

  CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.

• Description:

  This is a DNMT3B Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  DNMT3B, ICF, ICF1, M.HsaIIIB

• Gene ID:

  1789

• Swiss Prot:

  Q9UBC3

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide of human DNMT3B

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB, IF

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:200-1:1000 IF 1:50-1:200

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  77-95 kDa

• Observed Molecular Weight:

  110 kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG