RUNX2 Polyclonal Antibody

• Background:

  This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD) . Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.

• Description:

  This is a RUNX2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  RUNX2, AML3, CBF-alpha-1, CBFA1, CCD, CCD1, CLCD, OSF-2, OSF2, PEA2aA, PEBP2aA

• Gene ID:

  860

• Swiss Prot:

  Q13950

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant fusion protein of human RUNX2 (NP_001019801.3) .

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:200-1:1000

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  54 kDa/55 kDa/56 kDa

• Observed Molecular Weight:

  70 kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG