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Glisoxepide

CAT: 0804-HY-A0176-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-A0176-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Glisoxepide, a sulphonamide derivative, is an orally available nonselective K (ATP) channel blocker, with antihyperglycemic activity and cardiovascular regulation effect[1][2][3].
CAS Number
25046-79-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/glisoxepide.html
Purity
95.55
Solubility
DMSO : 4.5 mg/mL (ultrasonic; warming)
Smiles
O=C(C1=NOC(C)=C1)NCCC2=CC=C(S(=O)(NC(NN3CCCCCC3)=O)=O)C=C2
Molecular Formula
C20H27N5O5S
Molecular Weight
449.52
Precautions
H302, H315, H319, H335
References & Citations
[1]Sato T, et al. Bepridil, an antiarrhythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotection. J Pharmacol Exp Ther. 2006 Jan;316 (1) :182-8. Epub 2005 Sep 20.|[2]Selvaag E. Photohemolytic potency of oral antidiabetic drugs in vitro: effects of antioxidants and a nitrogen atmosphere. Photodermatol Photoimmunol Photomed. 1996 Aug;12 (4) :166-70.|[3]Fückel D, et al. Interaction of sulfonylureas with the transport of bile acids into hepatocytes. Eur J Pharmacol. 1992 Mar 31;213 (3) :393-404.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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