BIN1 Polyclonal Antibody

• Background:

  This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

• Description:

  This is a BIN1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  BIN1, AMPH2, AMPHL, SH3P9

• Gene ID:

  274

• Swiss Prot:

  O00499

• Reactivity:

  Human, Rat

• Immunogen:

  Recombinant fusion protein of human BIN1 (NP_647601.1) .

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB, IHC, IF

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:2000 IHC 1:50-1:200 IF 1:20-1:50

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  45-64 kDa

• Observed Molecular Weight:

  65 kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG