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UBE3A Polyclonal Antibody

CAT: 0866-RD82311A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD82311A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.
Description
This is a UBE3A Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
UBE3A, ANCR, AS, E6-AP, EPVE6AP, HPVE6A
Gene ID
7337
Swiss Prot
Q05086
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human UBE3A (NP_570853.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000 IHC 1:50-1:200
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
97 kDa/100 kDa
Observed Molecular Weight
110 kDa
Host or Source
Rabbit
Isotype
IgG

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