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CRACR2A Polyclonal Antibody

CAT: 0866-RD81616A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD81616A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Ca2+-binding protein that plays a key role in store-operated Ca2+entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
Description
This is a CRACR2A Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
CRACR2A, EFCAB4B
Gene ID
84766
Swiss Prot
Q9BSW2
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human CRACR2A (NP_001138430.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000 IHC 1:50-1:200
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
45 kDa/83 kDa
Observed Molecular Weight
45 kDa
Host or Source
Rabbit
Isotype
IgG

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