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CASC5 Polyclonal Antibody

CAT: 0866-RD81230A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD81230A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t (11;15) (q23; q14) . Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4) . Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed.
Description
This is a CASC5 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
AF15Q14, CASC5, CT29, D40, MCPH4, PPP1R55, Spc7, hKNL-1, hSpc105, KNL1
Gene ID
57082
Swiss Prot
Q8NG31
Reactivity
Human, Rat
Immunogen
Recombinant fusion protein of human CASC5 (NP_733468.3) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000 IHC 1:50-1:100
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
195 kDa/205 kDa/262 kDa/265 kDa
Observed Molecular Weight
300 kDa
Host or Source
Rabbit
Isotype
IgG

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