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ELANE Polyclonal Antibody

CAT: 0866-RD81185A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD81185A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN) . This gene is present in a gene cluster on chromosome 19.
Description
This is a ELANE Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
ELANE, ELA2, GE, HLE, HNE, NE, PMN-E, SCN1
Gene ID
1991
Swiss Prot
P08246
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human ELANE (NP_001963.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
28 kDa
Observed Molecular Weight
29 kDa
Host or Source
Rabbit
Isotype
IgG

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