Products for Research Use Only

ZBTB33 Polyclonal Antibody

CAT: 0866-RD81117A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD81117A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2) . Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-alpha2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.
Description
This is a ZBTB33 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
ZBTB33, ZNF-kaiso, ZNF348
Gene ID
10009
Swiss Prot
Q86T24
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human ZBTB33 (NP_006768.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:1000-1:3000
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
74 kDa
Observed Molecular Weight
74 kDa
Host or Source
Rabbit
Isotype
IgG