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FEN1 Polyclonal Antibody

CAT: 0866-RD80705A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD80705A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.
Description
This is a FEN1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
FEN1, FEN-1, MF1, RAD2
Gene ID
2237
Swiss Prot
P39748
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human FEN1 (NP_004102.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC, IF
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000 IHC 1:50-1:200 IF 1:10-1:100
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
35 kDa/42 kDa
Observed Molecular Weight
48 kDa
Host or Source
Rabbit
Isotype
IgG

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