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ABL1 Polyclonal Antibody

CAT: 0866-RD80028A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD80028A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t (9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410) . Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.
Description
This is a ABL1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
ABL, JTK7, p150, c-ABL, v-abl, CHDSKM, c-ABL1, ABL1, c-Abl, bcr/abl
Gene ID
25
Swiss Prot
P00519
Reactivity
Human, Rat
Immunogen
A synthetic peptide of human ABL1 (NP_005148.2) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC, IF
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000 IHC 1:100-1:200 IF 1:50-1:200
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
122 kDa/124 kDa
Observed Molecular Weight
139 kDa
Host or Source
Rabbit
Isotype
IgG

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