RAD50 Polyclonal Antibody

• Background:

  The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.

• Description:

  This is a RAD50 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  RAD50, NBSLD, RAD502, hRad50

• Gene ID:

  10111

• Swiss Prot:

  Q92878

• Reactivity:

  Human, Mouse

• Immunogen:

  A synthetic peptide of human RAD50

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB, IHC

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:2000 IHC 1:50-1:100

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  138 kDa/153 kDa/154 kDa

• Observed Molecular Weight:

  180 kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG