TXNIP Polyclonal Antibody

TXNIP Polyclonal Antibody

• Background: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
• Synonyms: THIF,VDUP1,HHCPA78,EST01027
• CAS Number: 9007-83-4
• Swiss Prot: Q9H3M7
• Accession Number: NP_006463
• Host: Rabbit
• Reactivity: Human,Mouse,Rat
• Immunogen: Synthetic peptide of human TXNIP
• Clonality: Polyclonal
• Isotype: IgG
• Conjugation: Unconjugated
• Applications: IHC,ELISA
• Purification: Affinity purification
• Concentration: 1.9 mg/mL
• Dilution: IHC 1:30-150, ELISA 1:2000-10000
• Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
• Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.