TXNIP Polyclonal Antibody

• Background:

  May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).

• Synonyms:

  THIF,VDUP1,HHCPA78,EST01027

• CAS Number:

  9007-83-4

• Swiss Prot:

  Q9H3M7

• Accession Number:

  NP_006463

• Host:

  Rabbit

• Reactivity:

  Human,Mouse,Rat

• Immunogen:

  Synthetic peptide of human TXNIP

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Conjugation:

  Unconjugated

• Applications:

  IHC,ELISA

• Purification:

  Affinity purification

• Concentration:

  1.9 mg/mL

• Dilution:

  IHC 1:30-150, ELISA 1:2000-10000

• Buffer:

  PBS with 0.05% sodium azide and 50% glycerol, PH7.4

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.