TXNIP Polyclonal Antibody

• Background :

  May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) .

• Description :

  This is a TXNIP Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms :

  THIF, VDUP1, HHCPA78, EST01027

• Swiss Prot :

  Q9H3M7

• Accession Number :

  NP_006463

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Synthetic peptide of human TXNIP

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Polyclonal Antibody

• Applications :

  IHC, ELISA

• Purification Method :

  Affinity purification

• Assay Type :

  Antibody

• Concentration :

  1.9 mg/mL

• Dilution :

  IHC 1:30-150, ELISA 1:2000-10000

• Buffer :

  PBS with 0.05% sodium azide and 50% glycerol, PH7.4

• Storage Conditions :

  Store at -20°C. Avoid freeze / thaw cycles.

• Host or Source :

  Rabbit

• Isotype :

  IgG