ABCC2 Polyclonal Antibody

• Background :

  The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.

• Description :

  This is a ABCC2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms :

  ABC30, abcC2, ATP binding cassette sub family C (CFTR/MRP) member 2, ATP binding cassette subfamily C member 2, ATP-binding cassette sub-family C member 2, Canalicular multidrug resistance protein, Canalicular multispecific organic anion transporter 1, CMOAT, CMO

• Swiss Prot :

  Q92887

• Accession Number :

  NP_000383

• Reactivity :

  Human

• Immunogen :

  Synthetic peptide of human ABCC2

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Polyclonal Antibody

• Applications :

  IHC, ELISA

• Purification Method :

  Affinity purification

• Assay Type :

  Antibody

• Concentration :

  0.6 mg/mL

• Dilution :

  IHC 1:30-150, ELISA 1:2000-10000

• Buffer :

  PBS with 0.05% sodium azide and 50% glycerol, PH7.4

• Storage Conditions :

  Store at -20°C. Avoid freeze / thaw cycles.

• Host or Source :

  Rabbit

• Isotype :

  IgG