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SPAG1 Polyclonal Antibody

CAT: 0866-RD78641A-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0866-RD78641A-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein.
Description
This is a SPAG1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
CILD28, FLJ32920, HSD-3.8, Infertility related sperm protein Spag 1, SP75, SPAG1, Sperm associated antigen 1, Tetratricopeptide repeat-containing protein, TPIS, TPR containing protein involved in spermatogenesis
Swiss Prot
Q07617
Accession Number
NP_003105
Reactivity
Human
Immunogen
Synthetic peptide of human SPAG1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, ELISA
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
0.3 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
104 kDa
Host or Source
Rabbit
Isotype
IgG

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