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Sertindole

CAT: 0804-HY-14543-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14543-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sertindole (Lu 23-174) is an orally active 5-HT2A, 5-HT2C, dopamine D2, and αl-adrenergic receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple cancer cells[1][2][3].
CAS Number
106516-24-9
Product Name Alternative
Lu 23-174
UNSPSC
12352005
Hazard Statement
H315, H319, H335, H413
Target
5-HT Receptor; Adrenergic Receptor; Autophagy; Dopamine Receptor
Type
Reference compound
Related Pathways
Autophagy; GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Sertindole.html
Purity
99.92
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
FC1=CC=C(N2C3=CC=C(Cl)C=C3C(C4CCN(CCN5CCNC5=O)CC4)=C2)C=C1
Molecular Formula
C24H26ClFN4O
Molecular Weight
440.94
Precautions
H315, H319, H335, H413
References & Citations
[1]David Murdoch, et al. Sertindole : a review of its use in schizophrenia. CNS Drugs. 2006;20 (3) :233-55.|[2]Wei Zhang, et al. Antiproliferative activities of the second-generation antipsychotic drug sertindole against breast cancers with a potential application for treatment of breast-to-brain metastases. Sci Rep. 2018 Oct 25;8 (1) :15753.|[3]Mario F Juruena, et al. Sertindole in the management of schizophrenia. J Cent Nerv Syst Dis. 2011 May 17;3:75-85.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT2 Receptor; α-1 microglobulin

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