DAB2 Polyclonal Antibody

CAT: 0866-RD78002A-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:0866-RD78002A-01Size:20 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Description
This is a DAB2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
DAB 2, Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila), DAB2, Differentially expressed in ovarian cancer 2, Differentially expressed protein 2, Disabled (Drosophila) homolog 2 (mitogen responsive phosphoprotein), Disabled homolog 2, Disabled homolog
Swiss Prot
P98082
Accession Number
BC003064
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein of human DAB2
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC, ELISA
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
0.6 mg/mL
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
82 kDa
Host or Source
Rabbit
Isotype
IgG

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