DAB2 Polyclonal Antibody

• Background:

  This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• Description:

  This is a DAB2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  DAB 2, Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila), DAB2, Differentially expressed in ovarian cancer 2, Differentially expressed protein 2, Disabled (Drosophila) homolog 2 (mitogen responsive phosphoprotein), Disabled homolog 2, Disabled homolog

• Swiss Prot:

  P98082

• Accession Number:

  BC003064

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein of human DAB2

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB, IHC, ELISA

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  0.6 mg/mL

• Dilution:

  WB 1:500-1:2000, IHC 1:50-1:200

• Buffer:

  PBS with 0.05% sodium azide and 50% glycerol, PH7.4

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  82 kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG