CAB39 Polyclonal Antibody

• Background:

  Peutz-Jeghers Syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules of the lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. The serine/threonine kinase LKB1 (also designated STK11) has been identified as the gene mutated in PJS. LKB1 activity increases upon the binding of a regulatory complex consisting of the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase and the calcium binding protein 39 (MO25 alpha) . STRAD and MO25 determine the subcellular localization of LKB1 by initiating its translocation from the nucleus to the cytoplasm, thus regulating the tumor suppressor activity of LKB1. The LKB1/STRAD/MO25 complex acts as an AMP-activated protein kinase kinase (AMPKK) .

• Description:

  This is a CAB39 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  Cab39, CAB39, Calcium binding protein 39, Calcium-binding protein 39, CGI 66, CGI-66, CGI66, MO25 alpha, MO25, Mouse protein 25 alpha, Protein Mo25

• Swiss Prot:

  Q9Y376

• Accession Number:

  NP_057373

• Reactivity:

  Human, Mouse

• Immunogen:

  Synthetic peptide of human CAB39

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB, IHC, ELISA

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1.7 mg/mL

• Dilution:

  WB 1:500-1:2000, IHC 1:50-1:200

• Buffer:

  PBS with 0.05% sodium azide and 50% glycerol, PH7.4

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  40 kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG