Products for Research Use Only
RegisterLogin

LCN2 Polyclonal Antibody

CAT: 0866-RD76511A-01Size: 20 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0866-RD76511A-01Size:20 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
Description
This is a LCN2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
24p3,25 kDa alpha 2 microglobulin related subunit of MMP9,25 kDa alpha-2-microglobulin-related subunit of MMP-9, Alpha 2 microglobulin related protein, HGNC:6526, HNL, Lcn 2, Lcn2, Lipocalin-2, Migration stimulating factor inhibitor, MSFI, Neutrophil gelatinase as
Swiss Prot
P80188
Accession Number
NP_005555
Reactivity
Human
Immunogen
Synthetic peptide of human LCN2
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC, ELISA
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
0.5 mg/mL
Dilution
IHC 1:25-1:100
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG

Related Products

CatalogName
RD87390A-01LCN6 Polyclonal Antibody
RD85371A-01LCN1 Polyclonal Antibody
RD81942A-01Polyclonal AntibodyPC1 Polyclonal Antibody
RD83593A-01Polyclonal AntibodyPC4 Polyclonal Antibody
RD77496A-01MAG Polyclonal Antibody
RD77501A-01MCM6 Polyclonal Antibody
RD219935A-01ATP5I Polyclonal Antibody
RD75037A-01TONSL Polyclonal Antibody
RD218583A-01CALHM1 Polyclonal Antibody
RD217759A-01CAD Polyclonal Antibody

Alternative Products

CatalogName
MBS8566795-01LCN2 Polyclonal Antibody
PTX18625-100LCN2 Polyclonal Polyclonal Antibody
AF7362LCN2 Rabbit Polyclonal Antibody

Popular Products