DDB1 Polyclonal Antibody

CAT: 0866-RD76230A-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:0866-RD76230A-01Size:20 µL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.
Description
This is a DDB1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
Damage specific DNA binding protein 1, Damage-specific DNA-binding protein 1, DDB 1, DDB p127 subunit, Ddb1, DDB1, DDBa, DNA damage binding protein 1, DNA damage-binding protein 1, DNA damage-binding protein a, HBV X-associated protein 1, UV damaged DNA binding fact
Swiss Prot
Q16531
Accession Number
NP_001914
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide of human DDB1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, ELISA
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
0.3 mg/mL
Dilution
WB 1:200-1:500
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
127 kDa
Host or Source
Rabbit
Isotype
IgG

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