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CASP12 Polyclonal Antibody

CAT: 0866-RD76201A-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:0866-RD76201A-01Size:20 µL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.
Description
This is a CASP12 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
CASP 12, CASP-12, Casp12, CASP12P1, caspase 12 (gene/pseudogene), caspase 12 pseudogene 1, CASPC, Inactive caspase-12, OTTHUMP00000207032
Swiss Prot
Q6UXS9
Accession Number
NP_001177945
Reactivity
Human, Mouse
Immunogen
Synthetic peptide of human CASP12
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC, ELISA
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
0.3 mg/mL
Dilution
IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG

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