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SRGAP3 Polyclonal Antibody

CAT: 0866-RD76121A-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0866-RD76121A-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SRGAP3 is a 1099 amino acid protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.
Description
This is a SRGAP3 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
ARHGAP 14, ARHGAP14, Gbi, ME GAP, MEGAP, Mental disorder associated GAP, Mental disorder-associated GAP, Rho GTPase activating protein 14, Rho GTPase-activating protein 14, SLIT ROBO Rho GTPase activating protein 3, SLIT-ROBO Rho GTPase-activating protein 3, srGAP 2
Swiss Prot
O43295
Accession Number
BC039300
Reactivity
Human, Mouse
Immunogen
Recombinant protein of human SRGAP3
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC, ELISA
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
0.6 mg/mL
Dilution
IHC 1:25-1:100
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG

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