AIM2 Polyclonal Antibody

• Background:

  Interferon-inducible protein AIM2 (Absent in melanoma 2) is a 343 amino acid protein belonging to the HIN-200 family. Induced by IFN-, AIM2 is thought to act as a tumor suppressor by repressing NFB transcriptional activity. Localized to the nucleus, AIM2 contains one DAPIN domain and one HIN-200 domain. The DAPIN domain is composed mostly of -helixes and is a protein-protein interaction domain capable of binding other DAPIN domains. The HIN-200 domain has been shown to bind directly to DNA, which, along with the binding of another protein ASC, results in the activation of Caspase-1.

• Description:

  This is a AIM2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  Absent in melanoma 2, AIM 2, Aim2, AIM2, Interferon-inducible protein AIM2, OTTHUMP00000035296, PYHIN4

• Swiss Prot:

  O14862

• Accession Number:

  BC010940

• Reactivity:

  Human

• Immunogen:

  Recombinant protein of human AIM2

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  IHC, ELISA

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  0.8 mg/mL

• Dilution:

  IHC 1:50-1:200

• Buffer:

  PBS with 0.05% sodium azide and 50% glycerol, PH7.4

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Host or Source:

  Rabbit

• Isotype:

  IgG