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FLT3 Polyclonal Antibody

CAT: 0866-RD75500A-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0866-RD75500A-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Description
This is a FLT3 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
CD 135, CD135, CD135 antigen, Fetal liver kinase 2, FL cytokine receptor, Flk 2, Flk2, Flt 3, FLT-3, Flt3, FLT3, FMS like tyrosine kinase 3, Fms related tyrosine kinase 3, Fms-like tyrosine kinase 3, Growth factor receptor tyrosine kinase type III, Ly-72, OTTHUMP00000042
Swiss Prot
P36888
Accession Number
BC126350
Reactivity
Human, Mouse
Immunogen
Recombinant protein of human FLT3
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC, ELISA
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
0.5 mg/mL
Dilution
IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG

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