ABL1 Polyclonal Antibody

• Background:

  The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t (9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.

• Description:

  This is a ABL1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine protein kinase 1, Abl 1, ABL, ABL proto oncogene 1 non receptor tyrosine kinase, ABL1, ABL1, bcr/abl, bcr/c abl oncogene protein, c ABL, c abl oncogene 1 non receptor tyrosine kinase, c abl oncogene

• Swiss Prot:

  P00519

• Accession Number:

  BC117451

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant protein of human ABL1

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  IHC, ELISA

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  0.5 mg/mL

• Dilution:

  IHC 1:50-1:200

• Buffer:

  PBS with 0.05% sodium azide and 50% glycerol, PH7.4

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Host or Source:

  Rabbit

• Isotype:

  IgG