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GSK3 beta Polyclonal Antibody

CAT: 0866-RD71253A-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0866-RD71253A-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which is critical for its role in bulge stem cell migration and skin wound repair.
Description
This is a GSK3 beta Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
Glycogen Synthase Kinase 3 Beta, Glycogen synthase kinase-3 beta, GSK 3 beta, GSK-3 beta, GSK3B, GSK3B, GSK3beta isoform, Serine/threonine-protein kinase GSK3B
Swiss Prot
P49841
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from human GSK3β around the non-phosphorylation site of Ser9.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC-p, IF, ELISA
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:100-1:300, ELISA 1:5000-1:20000
Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
47 kDa
Observed Molecular Weight
47 kDa
Host or Source
Rabbit
Isotype
IgG

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